NCCN VERSION 2 2015

NCCN Guidelines Version 2.2015 Breast Cancer

NCCN Guidelines Index Breast Cancer Table of Contents Discussion

304. Ingle JN, Tu D, Pater JL, et al. Intent-to-treat analysis of the placebo-controlled trial of letrozole for extended adjuvant therapy in early breast cancer: NCIC CTG MA.17. Ann Oncol 2008;19:877-882. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18332043 . 305. Perez EA, Josse RG, Pritchard KI, et al. Effect of letrozole versus placebo on bone mineral density in women with primary breast cancer completing 5 or more years of adjuvant tamoxifen: a companion study to NCIC CTG MA.17. J Clin Oncol 2006;24:3629-3635. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16822845 . 306. Whelan TJ, Goss PE, Ingle JN, et al. Assessment of quality of life in MA.17: a randomized, placebo-controlled trial of letrozole after 5 years of tamoxifen in postmenopausal women. J Clin Oncol 2005;23:6931-6940. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16157934 . 307. Jakesz R, Greil R, Gnant M, et al. Extended adjuvant therapy with anastrozole among postmenopausal breast cancer patients: results from the randomized Austrian Breast and Colorectal Cancer Study Group Trial 6a. J Natl Cancer Inst 2007;99:1845-1853. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18073378 . 308. Dowsett M, Cuzick J, Ingle J, et al. Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen. J Clin Oncol 2010;28:509-518. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19949017 . 309. Smith IE, Dowsett M, Yap Y-S, et al. Adjuvant aromatase inhibitors for early breast cancer after chemotherapy-induced amenorrhoea: caution and suggested guidelines. J Clin Oncol 2006;24:2444-2447. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16735701 . 310. Yu B, Douglas N, Ferin MJ, et al. Changes in markers of ovarian reserve and endocrine function in young women with breast cancer undergoing adjuvant chemotherapy. Cancer 2010;116:2099-2105. Available at: http://www.ncbi.nlm.nih.gov/pubmed/20187091 .

311. Dowsett M, Nielsen TO, A'Hern R, et al. Assessment of Ki67 in Breast Cancer: Recommendations from the International Ki67 in Breast Cancer Working Group. J Natl Cancer Inst 2011. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21960707 . 312. Dowsett M, Smith IE, Ebbs SR, et al. Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer. J Natl Cancer Inst 2007;99:167-170. Available at: 314. Schroth W, Goetz MP, Hamann U, et al. Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen. JAMA 2009;302:1429-1436. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19809024 . 315. Leyland-Jones B, Regan M, Bouzyk M, et al. Outcome according to CYP2D6 genotype among postmenopausal women with endocrine- responsive early invasive breast cancer randomized in the BIG 1-98 trial [abstract]. Cancer Res 2010;70(24 Suppl):Abstract nr S1-8. Available at: http://cancerres.aacrjournals.org/cgi/content/short/70/24_MeetingAbstra cts/S1-8 . 316. Rae J, Drury S, Hayes D, et al. Lack of Correlation between Gene Variants in Tamoxifen Metabolizing Enymes with Primary Endpoints in the ATAC Trial [abstract] Cancer Res 2010;70(24 Suppl):Abstract S1-7. Available at: http://cancerres.aacrjournals.org/cgi/content/meeting_abstract/70/24_M eetingAbstracts/S1-7?sid=e2c268c0-3fe1-481b-a9c9-01b32769a3d9 . 317. Higgins MJ, Stearns V. Pharmacogenetics of endocrine therapy for breast cancer. Annu Rev Med 2011;62:281-293. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21226615 . 318. Visvanathan K, Chlebowski RT, Hurley P, et al. American society of clinical oncology clinical practice guideline update on the use of http://www.ncbi.nlm.nih.gov/pubmed/17228000 . 313. Available at: http://www.cypalleles.ki.se/ .

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