NCCN VERSION 2 2015

NCCN Guidelines Version 2.2015 Breast Cancer

NCCN Guidelines Index Breast Cancer Table of Contents Discussion

advanced breast cancer. J Clin Oncol 2010;28:4594-4600. Available at: http://www.ncbi.nlm.nih.gov/pubmed/20855825 . 446. Leo AD, Jerusalem G, Petruzelka L, et al. Final analysis of overall survival for the Phase III CONFIRM trial: fulvestrant 500 mg versus 250 mg [abstract]. Cancer Res 2012;72 ( Suppl_24):Abstract S1-4 Available at: http://cancerres.aacrjournals.org/cgi/content/meeting_abstract/72/24_M eetingAbstracts/S1-4 . 447. Bergh J, Jonsson PE, Lidbrink EK, et al. FACT: an open-label randomized phase III study of fulvestrant and anastrozole in combination compared with anastrozole alone as first-line therapy for patients with receptor-positive postmenopausal breast cancer. J Clin Oncol 2012;30:1919-1925. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22370325 . 448. Mehta RS, Barlow WE, Albain KS, et al. Combination anastrozole and fulvestrant in metastatic breast cancer. N Engl J Med 2012;367:435-444. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22853014 . 449. Johnston S, Kilburn LS, Ellis P, et al. Fulvestrant alone or with concomitant anastrozole Vs exemestane following progression on non- steroidal aromatase inhibitor – First results of the SoFEa Trial [abstract]. European Journal of Cancer 2012;48, Supplement 3:Abstract S2. Available at: http://www.sciencedirect.com/science/article/pii/S0959804912706871 . 450. Buzdar A, Douma J, Davidson N, et al. Phase III, multicenter, double-blind, randomized study of letrozole, an aromatase inhibitor, for advanced breast cancer versus megestrol acetate. J Clin Oncol 2001;19:3357-3366. Available at: http://www.ncbi.nlm.nih.gov/pubmed/11454883 . 451. Buzdar AU, Jonat W, Howell A, et al. Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma: results of a survival update based on a

breast cancer: Follow-up analysis from the FIRST study [abstract]. San Antonio Breast Cancer Symposium 2010:Abstract S1-3. Available at: 440. Howell A, Robertson JFR, Quaresma Albano J, et al. Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment. J Clin Oncol 2002;20:3396-3403. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12177099 . 441. Osborne CK, Pippen J, Jones SE, et al. Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial. J Clin Oncol 2002;20:3386-3395. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12177098 442. Robertson JFR, Osborne CK, Howell A, et al. Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women: a prospective combined analysis of two multicenter trials. Cancer 2003;98:229-238. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12872340 . 443. Ingle JN, Suman VJ, Rowland KM, et al. Fulvestrant in women with advanced breast cancer after progression on prior aromatase inhibitor therapy: North Central Cancer Treatment Group Trial N0032. J Clin Oncol 2006;24:1052-1056. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16505423 . 444. Chia S, Gradishar W, Mauriac L, et al. Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: results from EFECT. J Clin Oncol 2008;26:1664-1670. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18316794 . 445. Di Leo A, Jerusalem G, Petruzelka L, et al. Results of the CONFIRM phase III trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptor-positive

Version 2.2015, 03/11/15 © National Comprehensive Cancer Network, Inc. 2015, All rights reserved. The NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN®. MS-99